Prognosis of patients with acute respiratory failure due to the SARS-CoV-2 501Y.V2 variant: a multicenter retrospective matched cohort studySARS-CoV-2 501Y.V2 변이로 인한 급성 호흡 부전 환자의 예후: 다기관 후향적 일치 코호트 연구Multicenter Study Published on 2022-05-242022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 28-day mortality 501Y.V2 Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARF Care Chronic kidney disease cohort study confounding variable confounding variables consecutive patient coronavirus enrolled evaluated extracorporeal membrane oxygenation Health Health care Health care system hospital Hospital mortality Hospitalized hypertension incidence intensive care intensive care unit Invasive mechanical ventilation island Kidney disease less Mortality multicenter Patient Prognosis prognosis of patient remained Respiratory failure retrospective SARS-CoV-2 saturated severe acute respiratory syndrome Coronavirus supported the SARS-CoV-2 university variant venovenous extracorporeal membrane oxygenation were infected [DOI] 10.1038/s41598-022-12767-4 PMC 바로가기 [Article Type] Multicenter Study
501Y.V2 spike protein resists the neutralizing antibody in atomistic simulations501Y.V2 스파이크 단백질은 원자 시뮬레이션에서 중화 항체에 저항합니다.Article Published on 2022-04-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 501Y.V2 antibody resistance atomic B.1.351 backbone binding caused CCS changed complex Complexes complexes COVID-19 pandemic COVID-19 vaccine design deaths distribution distributions experiment free energy free energy landscape indicated lead molecular molecular dynamics Mutation neutralizing antibody observation outbreak Protein reduced RMSD S protein SARS-CoV-2 SARS-CoV-2 variant significantly SMD SMD simulations spike Spike protein spike protein. the mean variant wild-type [DOI] 10.1016/j.compbiolchem.2022.107636 PMC 바로가기 [Article Type] Article
Neutralization Heterogeneity of UK and South African Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants in BNT162b2-Vaccinated or Convalescent Coronavirus Disease 2019 (COVID-19) Healthcare WorkersBNT162b2 백신 접종 또는 회복기 코로나바이러스 질환 2019(COVID-19) 의료 종사자의 영국 및 남아프리카 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 변이체의 중화 이질성Article Published on 2022-03-012022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African BNT162b2 BNT162b2 vaccine coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 detectable elicited forms HCW HCWs healthcare worker Mild NAb NAb titer NAbs Neutralizing Neutralizing antibodies neutralizing antibody respiratory SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus South Strains Vaccine vaccine. variants worker [DOI] 10.1093/cid/ciab492 PMC 바로가기 [Article Type] Article
BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease SeverityBNT162b2 메신저 RNA 백신 접종은 노인 요양원에서 중증 급성 호흡기 증후군 코로나바이러스 2 변이 501Y.V2의 발병을 예방하지는 못했지만 전염과 질병 중증도를 감소시켰습니다Article Published on 2022-02-112022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus BNT162b2 BNT162b2 vaccine coronavirus coronavirus 2 disease severity elderly home messenger Nursing nursing home outbreak Prevent reduced respiratory RNA SARS CoV-2 severe acute respiratory syndrome Coronavirus severe disease Transmission variant Variant. were infected [DOI] 10.1093/cid/ciab446 PMC 바로가기 [Article Type] Article
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchySARS-CoV-2 변이체는 면역 우세 계층이 이동된 항체 반응을 유발합니다Research Article Published on 2022-02-082022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta 501Y.V2 affected antibodies antibody Antibody Response B.1.351 B.1.351 variant Beta conserved delta variant determine Donor donors elicit elicited epitope Epitopes Frequency Human humans Immunity immunodominance immunodominant infected with SARS-CoV-2 Infection Influenza isolate isolates less mutant mutated Mutation neutralization Neutralizing activity polyclonal antibodies polyclonal antibody produced RBD Region residue SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serum Specificities specificity spike epitopes spike receptor-binding domain susceptibility the antibody response the RBD vaccination variant variants Viral viral isolates viral spike virus viruses while [DOI] 10.1371/journal.ppat.1010248 PMC 바로가기 [Article Type] Research Article
Emergency air evacuation of patients with acute respiratory failure due to SARS-CoV-2 from Mayotte to Reunion Island마요트에서 레위니옹 섬으로 SARS-CoV-2로 인한 급성 호흡 부전 환자의 긴급 대피Observational Study Published on 2021-12-032022-09-11 Journal: Medicine [Category] SARS, 변종, 임상, [키워드] 501Y.V2 6 hours Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age air evacuation ARF Case series case sery consecutive patient coronavirus curare death Emergency episode episode of evaluated extracorporeal membrane oxygenation Factor feasible hospital Hospitalized Hypoxemia ICU ICU admission intensive care intensive care unit Invasive mechanical ventilation island lack Mayotte median age observational study occurred Patient patients patients with SARS-CoV-2 Pneumonia positive receiving remained Respiratory failure retrospective SARS-CoV-2 SARS-CoV-2 pneumonia screened sedated severe acute respiratory syndrome Coronavirus severe hypoxemia Support tested the median the SARS-CoV-2 Transport Travel travel time Treatment university variant [DOI] 10.1097/MD.0000000000027881 PMC 바로가기 [Article Type] Observational Study
Severe Reinfection With South African Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant 501Y.V2남아프리카 중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 변종 501Y.V2에 의한 중증 재감염Comment Published on 2021-11-162022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V2 African coronavirus 2 respiratory SARS-CoV-2 South [DOI] 10.1093/cid/ciab129 PMC 바로가기 [Article Type] Comment
Unmethylated CpG motif-containing genomic DNA fragments of bacillus calmette-guerin improves immune response towards a DNA vaccine for COVID-19메틸화되지 않은 CpG 모티브를 함유한 바실러스 칼멧-게린의 게놈 DNA 단편은 COVID-19에 대한 DNA 백신에 대한 면역 반응을 향상시킵니다Article Published on 2021-10-012022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] 501Y.V2 acute respiratory syndrome acute respiratory syndrome coronavirus addition adjuvant Antibody titers B.1.1.7 Bacillus Calmette-Guérin BALB/c mice BC01 adjuvant caused Cellular immune response coronavirus coronavirus disease coronavirus- COVID-19 CpG disease DNA DNA fragment DNA vaccine effective elicit expressing Genome Genomic DNA humoral immune response immune responses IMPROVE mice neutralize neutralizing antibody Neutralizing antibody titer neutralizing antibody titers pandemic produced respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2. sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein tested the SARS-CoV-2 unmethylated Vaccine vaccine candidate variants [DOI] 10.1016/j.vaccine.2021.08.103 PMC 바로가기 [Article Type] Article
Therapeutic effect of CT-P59 against SARS-CoV-2 South African variantSARS-CoV-2 남아프리카 변종에 대한 CT-P59의 치료 효과Article Published on 2021-08-202022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V2 African antibody Antiviral effect B.1.1.7 B.1.1.7 variant B.1.351 binding binding affinity circulation comparable COVID-19 patient COVID-19 patients CT-P59 decrease demonstrated dosage effective Efficacy immune evasion in vitro in vivo K417N less Live virus monoclonal antibody mutant Mutation N501Y neutralization assays neutralized Neutralizing activity Pseudovirus neutralization assay public health RBD Receptor binding domain reduced regdanvimab respiratory respiratory tracts SARS-CoV-2 SARS-CoV-2 virus shown South therapeutic therapeutic antibodies Therapeutic antibody therapeutic potential Transmissibility upper and lower respiratory tracts Vaccine variant Variant. variants variants of SARS-CoV-2 Viral Viral load virus wild type [DOI] 10.1016/j.bbrc.2021.06.016 PMC 바로가기 [Article Type] Article
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection헤스페리딘은 SARS-CoV-2 감염에 대한 잠재적 억제제입니다Article Published on 2021-08-162022-09-10 Journal: Nutrients [Category] MERS, SARS, 변종, [키워드] 501Y.V2 ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aglycone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bioavailability cellular cellular entry cellular receptor coronavirus D614G docking hesperetin hesperidin Infection Interaction metabolite Particles Potential Proteins reducing reduction required respiratory S protein SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus shown suppressed the S protein the SARS-CoV-2 TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor transmembrane serine protease transmembrane serine protease 2 variants variants of SARS-CoV-2 VeroE6 cell VeroE6 cells wild type [DOI] 10.3390/nu13082800 PMC 바로가기 [Article Type] Article